Outline of P&D Project
NISHIKAWA Hiroyoshi PM
(Nagoya University, Professor）
We will elucidate the mechanism of the inflammation-precancerous state-carcinogenesis transition and establish novel technologies to detect cancer-initiating cells at an ultra-early stage based on immune-genomic analysis. We will also work on preventive medicine and new drug discovery / development using wearable devices, etc. The Japan-U.S. team will strongly pursue this program to realize a "society with zero incidence of cancer".
Expected Breakthroughs by 2040
- Elucidation of the mechanisms that determine the transition of inflammation - precancerous state - carcinogenesis, and predicting the risk of carcinogenesis induced by chronic inflammation for each individual by integrating mathematical modeling research based on large-scale cohort data.
- Establishing a new platform for comprehensive immune-genomic analysis to detect the emergence of cancer-initiating cells as well as changes of intra- and intercellular networks at an extremely early stage.
- Development of a novel in vivo monitoring system using easily collected specimens to optimize when and to whom medical intervention require, thereby realizing prevention and ultra-early preemptive medicine.